Intranasal Ketamine and Esketamine Infusion

Intranasal ketamine infusion is a dissociative anesthetic that is administered through the nose and is absorbed into the bloodstream. Eskteamine is an altered form of ketamine. They are both used to treat adults with treatment-resistant depression.

Our Capabilities

We are certified in Risk Evaluation and Mitigation Strategy (REMS) for esketamine treatment and are the region’s only premier provider for treatment-resistant depression.

Compassionate Healing Starts Here

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Our team of subspecialists offer hope to patients with mood disorders through innovative treatments and compassionate care. We know that diagnosing mood disorders early is crucial to managing your condition and offering you the best quality of life. At UC Health, we focus on identifying predictors of mood disorders, as well as studying new interventions backed by leading research to bring you the best possible care.

To schedule an appointment, please call the UC Health Mood Disorders team at 513-558-MOOD (6663).

Help Along the Way

Answers to Your Intranasal Ketamine and Esketamine Infusion Questions

Ketamine blocks an important nerve cell receptor, called the NMDA receptor, which is located in nerve cells that would otherwise be stimulated by a neurotransmitter called glutamate. Depression has been linked to activity changes in areas of the brain stimulated by these nerve cells, and ketamine has been hypothesized to work by influencing these brain regions. In clinical studies, some patients reported rapid relief in their symptoms of depression.

We administer the infusions in our officers using an atomizer or inhaler that is applied to both nostrils. After receiving the infusion, patients are watched closely for an hour and are then asked to remain in our waiting area for an additional hour to monitor for possible side effects.

Intranasal ketamine and esketamine infusions can quickly improve medication-resistant depression symptoms in adults. Each patient is different and some may notice benefits over a longer period of time. During treatment, a psychiatrist will consult with you to evaluate your progress.

Intranasal ketamine and esketamine infusions are painless treatments, and most patients receive four to eight treatments over the two-week period. 

For safety, patients cannot drive following treatment. Any potentially serious side effects will be discussed in detail prior to receiving the infusions.

Why UC Health?

Experience and Expertise

Most Experience

UC Health has the most experience in the region providing intranasal ketamine and esketamine infusions to adult patients suffering from medication-resistant depression.

Innovative Options

We have access to new, innovative treatment options like ketamine that can help individuals with depression who have been resistant to the usual treatments.

Care Just Around The Corner

Getting treatment closer to where you live makes a big difference. Because intranasal administration does not require intravenous access, it can be done in our offices.

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Referring Physicians: Success and Provider Toolbox

We are committed to providing optimal care to your patient and open communication with you. We understand that as a referring physician, you need to be kept informed on your patient’s progress. That’s why we set up a toolbox to share detailed information about your patient’s health with you.

For referral information, call:

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At UC Health, we lead the region in scientific discoveries and embrace a spirit of purpose – offering our patients and their families something beyond everyday healthcare. At UC Health, we offer hope.

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