Medications for Opioid Use Disorder
Methadone
Methadone is a daily medication that helps prevent withdrawal symptoms and reduce cravings for opioids. It works by activating the same receptors as opioids, but in a slow and steady way, so you don’t get “high.” This helps stabilize your body and supports recovery.
Buprenorphine (Suboxone®)
Buprenorphine helps reduce cravings and withdrawal symptoms while lowering the risk of overdose. It partially activates opioid receptors, which is enough to help you feel well without causing a full opioid effect. Suboxone® also contains naloxone to discourage misuse.
Long-acting Buprenorphine (Brixadi®, Sublocade®)
These are long-acting forms of buprenorphine given as weekly or monthly injections. They work the same way as daily buprenorphine but provide steady medication levels over time, so you don’t need to take a daily dose. This can make treatment simpler and more consistent.
Long-acting Naltrexone (Vivitrol®)
Vivitrol® is a monthly injection that blocks the effects of opioids. It does not reduce cravings the same way as methadone or buprenorphine, but it prevents opioids from producing a high. You must be fully off opioids before starting this medication.