Improving Neurotrauma By Depolarization Inhibition With Combination Therapy (Indict): A Phase 2 Randomized, Feasibility Trial
Posted Date: Nov 4, 2025
- Investigator: Jed Hartings
- Specialties: Neurosurgery, Neurotrauma
- Type of Study: Device
The long-term objective is to determine whether treatment guided by electrocorticographic (ECoG) monitoring of spreading depolarizations (SDs) improves outcomes in patients who require surgery for severe TBI. The primary goals of this study are to determine (1) the feasibility of implementing a treatment protocol for intensive care of severe TBI that is guided by real-time SD monitoring, and (2) the effects of this protocol to reduce secondary injury and improve cerebral physiology.
Criteria:
Emergency Craniotomy Or Craniectomy To Treat Acute Tbi Within 72 Hours Post Trauma, Age 18-80, Placement Of Subdural Electrode Strip For Neuromonitoring During Emergency Craniotomy Procedure.
Keywords:
Tbi, Acute
For More Information:
Jennifer Goldthwait
513-558-8680
goldthjd@ucmail.uc.edu