University of Cincinnati Cancer Center | UCCC

Contact and Appointments: (513) 475-8500

High Risk Clinic

High Risk Programs

The Breast and Ovarian Cancer High Risk Programs exist to promote awareness about breast and ovarian cancer risk to patients, families and healthcare providers. The programs provide an expert evaluation for patients who are identified as high risk for either breast or ovarian cancer. After a patient is evaluated, he or she is offered appropriate counseling, testing and primary prevention measures to reduce the likelihood of cancer deployment. This multidisciplinary approach to women’s cancer risk assessment and management (RAMP) will utilize the services of breast imaging and genetics along with gynecologic oncology, surgical oncology and medical oncology.

Who Would Be Considered High Risk?

  • A person who has one or more first-generation relatives with breast or ovarian cancer before the age of 50.
  • An individual who has one first-generation relative with bilateral breast cancer.
  • Individuals with a known personal or family genetic abnormality in a breast cancer-causing gene, such BRCA or CHEK–2.
  • A person with prior breast biopsy showing atypical ductal hyperplasia or lobular neoplasia.
  • Individuals with a Gail Model breast cancer risk of greater than or equal to 1.67 percent over the next five years or greater than a 20 percent lifetime risk.
  • An individual with a history of chemoradiotherapy to treat Hodgkin’s disease.

Always Practice Breast Awareness

Let your healthcare provider know if you notice any:

  • New breast lumps.
  • Skin changes (retraction of the skin or the appearance that skin is being pulled inward, dimpling of your breast skin, leathering or thickening of your skin, or redness).
  • Pain in one specific part of your breast that will not go away.
  • Nipple discharge that is from one side, spontaneous, and is clear or bloody.

Ways You Can Reduce Your Risk

Live a Healthy Lifestyle

  • Moderate exercise can reduce your risk by approximately 20 percent. 30 minutes daily, five days per week (150 minutes per week)
  • Less than five alcoholic beverages per week.
  • Weight control, including a healthy diet.
  • Eat more fruits and vegetables and avoid processed foods and sugars.
  • No smoking or tobacco products.

Preventative Surgery

  • Bilateral mastectomies can reduce your risk by at least 90 percent.
  • Removal of ovaries can reduce risk by approximately 50 percent.

Certain Medications can Reduce Your Risk of Developing a Hormone Receptor by 50 Percent

  • Selective estrogen receptor moderators (tamoxifen).
  • Aromatase inhibitors.

If You Are at Risk:

  • Consider receiving genetic testing and counseling.
  • Consider increased breast screening: Clinical breast exam every 6-12 months.
  • Screening mammograms every 12 months (not to start before 30 years of age).
  • Consider 3D mammograms for increased visibility.
  • Consider breast MRIs every 12 months beginning after


University of Cincinnati Cancer Institute’s Breast Cancer Center
Barrett Cancer Center

For more information, visit Contact your UC Health High Risk Team for questions or to schedule an appointment at 513-584-RISK.


High Risk Checklist