Health Insights

Getting Help for Mood Disorders with UC Health

Apr. 30, 2025

Everyone experiences emotional ups and downs, but for some, these shifts in mood become intense, persistent, and life-disrupting. At UC Health, expert psychiatric care offers real hope for mood disorder treatment right here in Greater Cincinnati.


At UC Health, we’re more than a hospital system. We're Cincinnati’s only academic health center, where world-class psychiatric research meets compassionate, evidence-based care. Mood disorders are more than occasional sadness or mood swings; they are serious mental health conditions that can interfere with daily functioning, relationships, and overall quality of life. From depression to bipolar disorder, these conditions affect millions of people and often appear alongside other mental health issues like anxiety, OCD, or PTSD. At UC Health, we bring deep expertise to some of the most common, yet often misunderstood, health conditions.

Did You Know?

  • Mental illnesses are among the most common health conditions in the United States.
  • 1 in 5 American adults experienced mental illness in 2023, according to the National Survey on Drug Use and Health (NSDUH).
  • 1 in 20 American adults experienced serious mental illness, the same study found.

May is Mental Health Month, and as a national leader in treating mood disorders, such as major depression, bipolar disorder, as well as other psychiatric illnesses such as anxiety disorders, psychotic disorders, substance use disorders, and cognitive impairment, UC Health’s Mood Disorders Center is uniquely equipped to confront these statistics with advanced treatments not available elsewhere in the region.

What are Mood Disorders?

Mood disorders are a mental health condition that affects a person’s emotional state. These emotional states can significantly affect a person’s life, sometimes even becoming debilitating. They involve periods of depression, elevated mood, or a combination of both. Mood disorders are distinct from other mental health conditions like anxiety disorders, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD), although these conditions often co-occur with mood disorders. The good news? There is help. Most mood disorders can be treated with medications, therapy, good support, strong support networks, and self-care.

What Causes Mood Disorders?

There are many things that can cause a mood disorder.

  • Biological: The brain is responsible for controlling feelings, and an imbalance of chemical messengers in the brain can cause mood disorders.
  • Genetic: Genetics are responsible for passing down more than eye and hair color. If a family member has a mood disorder, it is more likely to be passed down genetically.  
  • Environmental: Stressful life events such as giving birth, the death of a loved one, a difficult illness (such as cancer), or a traumatic event can bring on a mood disorder such as depression.

What Types of Mood Disorders do We Treat at UC Health?

At UC Health, we specialize in treating mood disorders, focusing on depressive and bipolar spectrum illnesses. We also provide care for common psychiatric conditions that often occur alongside mood disorders.

Primary Mood Disorders:

  • Major Depressive Disorder: Characterized by a persistent low mood, loss of interest or pleasure in activities, and physical symptoms such as changes in sleep, appetite, and energy. Episodes typically last for weeks or months.
  • Persistent Depressive Disorder (Dysthymia)A chronic form of depression with less severe but longer-lasting symptoms, often persisting for two years or more.
  • Bipolar I Disorder: Defined by episodes of mania (abnormally elevated or irritable mood and high energy) that may be accompanied by episodes of depression.
  • Bipolar II Disorder: Involves patterns of depressive episodes and hypomania (less severe manic episodes), without full manic episodes.
  • Cyclothymic Disorder: A milder form of bipolar disorder characterized by frequent mood swings between periods of mild depression and hypomania over an extended period.

Common Comorbid Conditions:

Although not mood disorders themselves, the following conditions frequently occur alongside mood disorders and are treated comprehensively at UC Health.

  • Anxiety Disorder: Present in 50–60% of individuals with mood disorders, anxiety disorders involve excessive fear, worry, physical symptoms like sweating or nausea, and difficulty concentrating or sleeping.
  • Obsessive-Compulsive Disorder (OCD): OCD involves intrusive, unwanted thoughts (obsessions) and repetitive behaviors (compulsions) performed to reduce anxiety. About 20% of individuals with mood disorders experience comorbid OCD.
  • Post-Traumatic Stress Disorder (PTSD): This condition can occur after traumatic events and includes symptoms such as intrusive memories, hypervigilance, and emotional numbness. PTSD co-occurs with mood disorders in up to 40% of cases.
  • Attention Deficit Hyperactivity Disorder (ADHD): ADHD is a neurodevelopmental disorder marked by impulsivity, hyperactivity, and difficulty sustaining attention. It is comorbid with mood disorders in approximately 15–20% of adults.
  • Substance Use Disorders: Substance misuse occurs in about 40% of people with bipolar disorder, complicating the course and treatment of mood disorders.
Woman gets support from a healthcare worker in an office setting

How do We Treat Mood Disorders at UC Health?

There are many ways that mood disorders can be treated. Some of the more common treatments are the use of psychiatric medications, therapy/counseling, and teaching self-care strategies. Some of the more unique treatments that can be found at UC Health, but at few other healthcare systems in the region, are:

  • Transcranial Magnetic Stimulation (TMS): TMS therapy is a safe, non-invasive treatment for depression, especially when other treatments have not been effective. It uses magnetic fields to stimulate electric activity in nerve cells in the brain, specifically targeting areas thought to be associated with mood control.
  • Electroconvulsive Therapy (ECT): ECT quickly relieves severe depression symptoms and other psychiatric issues when other treatments fail. Under anesthesia, brief electrical stimulation to the brain can rapidly improve severe psychiatric syndromes, including those that have failed multiple other treatment modalities.
  • Intranasal Ketamine & Esketamine Treatments: Intranasal ketamine is a dissociative anesthetic that is administered through the nose and is absorbed into the bloodstream. Esketamine is an altered form of ketamine. Intranasal ketamine and esketamine are both used to treat adults with treatment-resistant depression.

Getting Help for Mood Disorders

Mental illness is common. High-quality, effective treatment should be, too. That’s our mission at UC Health in Cincinnati. With specialized services that include advanced therapies like transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), and esketamine, we offer more than what’s available in a typical clinic. Here, you’ll find a team trained to manage even the most treatment-resistant mood disorders—all backed by the latest research and a deep understanding of what patients need to feel better.

If you or a loved one would like more information about mood disorders or would like to schedule an appointment, visit UC Health Mood Disorders or call: 513-585-MOOD (6663).

Other Important Phone Numbers:

  • 513-585-8227: Addiction Services
  • 513-584-5098: UC Health Mobile Crisis Team (Hamilton County Residents)
  • 513-584-8577: UC Health Psychiatric Emergency Services
  • 988: Suicide and Crisis Lifeline

Medical Review by:

Psychiatry & Behavioral Science
Practices: Mood Disorders
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