Clinical Study

The Relationship Between Depression And Mitochondrial Disease

Posted Date: Aug 31, 2020

  • Investigator: Amanda Porter
  • Specialties:
  • Type of Study: Observational/Survey

Depression is a leading cause of disability in the United States. Up until this point in time, the most widely accepted theory as to the etiology of depression is the monoamine theory; a mainstay of treatment for depression has been pharmacological antidepressants, which correct the imbalance of monoamines. However, even with correct diagnosis and appropriate treatment, complete remission evades a large number of patients. With such a poor prognosis, it behooves the clinician to consider etiologies other than the monoamine theory for depression, such as mitochondrial disease. The research question for this proposed dissertation study is, What is the relationship between mitochondrial disease and depression? The population studied will be archival data of adult patients treated for Major Depressive Disorder and Bipolar Depression at the Lindner Center of HOPE, a free-standing mental health facility in Mason, Ohio. The patient charts will be reviewed for data that were already obtained from patients in the form of Hamilton Depression Rating Scores along with serum lab values of glutathione, zinc, and riboflavin. A nonparametric correlational test will reveal a relationship between the mitochondrial biomarkers and Hamilton-D scores. This dissertation study will contribute evidence to address the gap of quantitative studies that have been conducted with subjects with moderate to severe depression to solidify reveal a relationship between the presence of mitochondrial disease in patients and with depression




Depression, Mitochondria

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Amanda Porter

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