Clinical Study

Changes In Novel Plasma Secretory Proteins Among Patients Undergoing Transcatheter Mitral Valve Intervention And Impact On Outcome

Posted Date: Feb 16, 2023

  • Investigator: Demetrio Sharp Dimitri
  • Specialties: Cardiology, Cardiovascular Disease
  • Type of Study: Observational/Survey

Background: Mitral regurgitation (MR) is the most common cause of valvular heart disease in the US. Once severe, it is associated with up to 50% mortality at 5 years if untreated. In prohibitive surgical risk patients with primary severe MR and those with severe functional MR on maximum tolerated heart failure guideline-directed medical therapy, transcatheter catheter mitral valve repair with the Mitraclip has become the mainstay of treatment. Significant improvements in mortality and outcomes noted in COAPT Trial have led to FDA approval of Mitraclip. Recent data from Dörr et al demonstrated platelet dysfunction in a subset of patients along with elevation of plasma inflammatory markers, which was predictive of 6-month mortality. Complementing this data, our lab demonstrated changes in endosomal trafficking among patients undergoing Mitraclip with implications on the release of platelet-derived cargo in the context of inflammation. Based on these findings, our goal is to evaluate changes in novel plasma secretory proteins following Mitraclip and evaluate the impact on the outcome. Objectives: This study aims to determine changes in plasma proteome following Mitraclip using data-independent acquisition and target data analysis-based mass spectrometry and correlate with clinical outcomes. Hypothesis: We hypothesize that changes in the set of plasma proteins will predict outcomes following Mitraclip and correlate with platelet function and inflammation measures. Experimental plans: Mass spectrometry-based proteomics will be used to evaluate changes in plasma biomarkers following Mitraclip. Differential expression analysis will be utilized to evaluate changes in plasma proteins. These biomarkers will then be correlated with post-procedural outcomes using Spearman correlation.




Transcatheter Mitral Valve Intervention, Mitral Clip, Outcome Predictors

For More Information:

Demetrio Sharp Dimitri,Md

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