Brain Oxygen Optimization In Severe Tbi, Phase 3 (Boost3)
Posted Date: Nov 4, 2025
- Investigator: Natalie Kreitzer
- Specialties: Emergency Medicine, Neurotrauma
- Type of Study: Device
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In both strategies the monitoring and goals help doctors adjust treatments including the kinds and doses of medications and the amount of intravenous fluids given, ventilator (breathing machine) settings, need for blood transfusions, and other medical care. The results of this study will help doctors discover if one of these methods is more safe and effective.
Criteria:
Non-Penetrating Traumatic Brain Injury, Glasgow Coma Scale 3-8 Measure Off Paralytics, Evidence Of Intracranial Trauma On Ct Scan, Able To Place Intracranial Probes And Randomize Within 6 Hours Of Arrival At Enrolling Hospital, Able To Place Intracranial Probes And Randomize Within 12 Hours From Injury.
Keywords:
Tbi, Acute
For More Information:
Tricia Sarkar
513-558-5281
sarkarta@ucmail.uc.edu