Clinical Study

Effects Of Plasma Exchange On Adolescent And Adult Patients With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (Pandas)

Posted Date: Jan 21, 2021

  • Investigator: Caroline Alquist
  • Specialties: Adolescent Psychiatry/Psychology, Neurology, Psychiatry/Psychology
  • Type of Study: Observational/Survey

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is a rare disease entity typically diagnosed in childhood after the sudden onset of new neuropsychiatric symptoms, such as severe obsessive-compulsive disorder. While this entity is defined as starting in childhood, many adolescents and adults are not immediately diagnosed due to relative lack of knowledge about this disease, combined with the difficulty of diagnosis given a lack of definitive diagnostic criteria. Therefore, many patients are not diagnosed until later in life, making treatment decisions more complicated. Currently, therapeutic plasma exchange is a recommended therapy for this entity, but there is little to no data on this age group regarding the efficacy of this treatment modality for PANDAS. Our study aims to retrospectively review patients treated with plasma exchange for PANDAS and assess this method of treatment for this entity in adolescent and adult patients.


This Is A Retrospective Study Of Patients With Pandas. Eligibility Includes Being An Adult Or Adolescent Patient Who Has Been Diagnosed With Pandas And Has Received Therapeutic Plasma Exchange For Symptom Management.


Apheresis, Pandas

For More Information:

Caroline R Alquist

  • This contact page is monitored Monday – Friday during business hours, 8 am to 5 pm EST. Do not rely on communication through this website for medical treatment or care. This website is not designed for such purposes.
    For questions regarding clinical studies at UC Health, contact us at or (513) 245-3417.