Measuring Unbound Parathyroid Hormone Levels In Blood And Saliva
Posted Date: Jun 10, 2019
- Investigator: Alice Tang
- Specialties: Otolaryngology, Thyroid Cancer
- Type of Study: Device
Parathyroid hormone (PTH) is synthesized by the chief cells of the parathyroid glands. Intact PTH is an 84 amino acid polypeptide which maintains calcium homeostasis. The measurement of rapid intraoperative/perioperative PTH is crucial to the appropriate surgical management of parathyroid adenomas and hyperplasia. Additionally, PTH measurement is important in post-operative medical management of total thyroidectomies. Parathyroidectomy is the standard of care for treatment of primary and tertiary hyperparathyroidism refractory to medical management. Utilizing preoperative imaging (e.g. Sestamibi scans, ultrasound) to identify abnormal parathyroid glands, measuring rapid intraoperative PTH levels, and correlating with intraoperative frozen pathology have decreased operating times and resulted in a paradigm shift from the traditional bilateral neck four gland exploration. During total thyroidectomies, the close proximity of the parathyroid glands to the thyroid, these glands may be inadvertently removed or disturbed during surgery necessitating the measurement of PTH levels, due to early post- operatively to predict development of hypocalcemia. PTH regulates serum levels of calcium through its effects on bone, intestines, and kidneys. At low calcium levels, side effects include perioral numbness and paresthesia of the hands and fingers to more severe muscle cramps, convulsions, and even death.
Criteria:
Null
Keywords:
Parathyroid Hormone, Thyroid Disease
For More Information:
Becky
558-1719
gibsonrk@uc.edu